Table 1.
Mediation proportion of inflammatory proteins in the causal effect of immune cells on knee OA
| Immune cell | Protein | β_all | β1 | β2 | Mediation proportion | P |
|---|---|---|---|---|---|---|
| CD25 on IgD + CD24 + B cell | TRAIL | − 0.0314 | − 0.0420 | 0.0013 | 0.0107 | 10.99% |
| CD16-CD56 on NKT | TRAIL | 0.0340 | − 0.0420 | − 0.0014 | − 0.0186 | 7.13% |
| Activated & secreting CD4 regulatory T cell %CD4 + T cell | TRAIL | − 0.0096 | − 0.0420 | 0.0004 | 0.0056 | 6.72% |
| HLA DR on CD14 + CD16 + monocyte | IL17C | − 0.0166 | 0.0310 | − 0.0005 | − 0.0115 | 4.28% |
| IgD on IgD + CD38br | TRAIL | 0.0293 | − 0.0420 | − 0.0012 | − 0.0288 | 4.11% |