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. 2005 Jun 10;7(5):R971–R983. doi: 10.1186/ar1768

Figure 2.

Figure 2

Amino acid sequences of expressed Vλ regions compared with their closest germline λ gene, 2a2. The amino acid sequences of B3VL, B3(R27aS)VL, B33VL, BUVL, 33.H11VL, and UK-4VL regions are numbered according to the system of Wu and Kabat [26]. Amino acids are indicated by their one-letter code. Dots have been inserted to facilitate the alignment. A dash indicates sequence identity with that of germline gene 2a2. The complementarity-determining regions (CDRs) and framework regions (FRs) have been defined according to the system of Wu and Kabat [26]. Antigen contact sites, as defined by MacCallum and colleagues [27], are shown by red arrows. L1, L2 and L3 are the first, second and third contact regions of the light chain respectively.