. 2005 Jun 23;7(5):R1034–R1045. doi: 10.1186/ar1779

Table 3.

Ratio of RANKL to OPG in mice with collagen-induced arthritis

	CIA	CIA + VIP
RANKL	51.20 ± 3.57	13.08 ± 2.45^a
OPG	1.46 ± 0.27	2.46 ± 0.92
RANKL/OPG	35.09 ± 3.18	5.30 ± 0.95^a

The mRNA expression for RANKL and OPG in hind paws of mice with collagen-induced arthritis (CIA) was measured by quantitative real time PCR and corrected by mRNA expression for β-actin in each sample. On day 10 of vasoactive intestinal peptide (VIP) treatment, differences between the arthritic group and the CIA group treated with VIP were statistically significant (^ap < 0.001). Results are the mean ± SEM of two independent experiments with 10 animals per group. OPG, osteoprotegerin; RANKL, receptor activator of nuclear factor-κB ligand.