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. Author manuscript; available in PMC: 2025 Oct 31.
Published in final edited form as: Am J Physiol Endocrinol Metab. 2025 Sep 12;329(5):E707–E718. doi: 10.1152/ajpendo.00084.2025

Figure 1.

Figure 1.

ELISA assays of rabbit blood serum following injections of 0.6, 1, and 30 μg per kg rabbit mass. High doses of ACTH1–24 increased serum ACTH1–24, Cortisol, VEGF and glucose at 4 hours, green and purple traces. At 0.6 μg per kg, the concentration used in long-term studies, ACTH1–24 (red symbols) did not measurably increase serum ACTH1–24 (A), cortisol (B), or glucose (D), but did increase serum VEGF (C) at four hours (p <0.0001); VEGF was also increased by 1 μg per kg rabbit mass. 30 μg per kg did not affect VEGF, interestingly. Effects on glucose (D) were inconsistent at short times, but increased at the two higher doses, (p <0.003), at four hours.