Table 3.
List of genes potentially specifically involved in neoplastic progression in MMTV-Wnt-1 transgenic mice
| Expression ratio | |||||
| Image ID | Gene name | Symbol | WntH/V | WntT/WntH | WntT/NeuT |
| 474107 | Tumor necrosis factor receptor superfamily, member 19 | Tnfrsf19 | 2.56 | 3.48 | 6.23 |
| 406897 | Retinol binding protein 1, cellular | Rbp1 | 2.93 | 3.02 | 1.96 |
| 572428 | Cell cycle cyclin D1 Mm.35804 Cyclin D1 | Ccnd1 | = | 5.53 | 1.97 |
| 536306 | Hormone/GF growth/diff 1 Mm.22621 Procollagen type I α1 | Col1a1 | = | 3.04 | 3.27 |
| 536526 | ESTs | = | 8.8 | 5.95 | |
| 329780 | Cadherin 3 | Cdh3 | = | 3.74 | 3.96 |
| 427360 | Mus musculus, clone IMAGE:3590270, mRNA, partial cds | LOC192176 | = | 3.5 | 2.44 |
| 638805 | Expressed sequence AI504637 | = | 3.3 | 2.27 | |
| 355990 | Chondroitin sulfate proteoglycan 2 | Cspg2 | = | 3.62 | 5.05 |
| 574500 | ESTs | = | 4.13 | 1.65 | |
| 476431 | Nerve growth factor receptor | Ngfr | = | 3.61 | 6.34 |
| 680894 | Glial cell line derived neurotrophic factor family receptor α1 | Gfra1 | = | 4.74 | 4.05 |
| 482943 | Odd-skipped related 1 (Drosophila) | Osr1 | = | 4.1 | 3.65 |
| 695687 | Calponin 2 | Cnn2 | = | 3.49 | 2.54 |
| 335572 | Dihydropyrimidinase-like 3 | = | 3.27 | 7.61 | |
| 621246 | Interferon concensus sequence binding protein | Icsbp | = | 3.38 | 4.91 |
| 482170 | Four jointed box 1 (Drosophila) | Fjx1 | = | 4.13 | 3.78 |
| 468019 | IL-17b | Il17b | = | 4.27 | 5.37 |
| 373716 | Tumor-associated calcium signal transducer 2 | Tacstd2 | = | 4.16 | 3.69 |
| 479405 | ESTs | = | 3.01 | 4.95 | |
| 722262 | Wingless-related MMTV integration site 5A | Wnt5a | = | 4.44 | 9.23 |
| 719592 | GATA binding protein 2 | Gata2 | = | 6.06 | 10.54 |
| 1247541 | Apolipoprotein D | Apod | = | 4.67 | 3.86 |
| 331186 | Caveolin, caveolae protein, 22 kDa | Cav1 | 0.31 | 0.29 | 3.67 |
| 596968 | Caveolin, caveolae protein, 22 kDa | Cav1 | 0.3 | 0.31 | 3.05 |
| 948509 | Caveolin, caveolae protein, 22 kDa | Cav1 | 0.52 | 0.18 | 3 |
| 386555 | CD36 antigen | Cd36 | 0.21 | 0.06 | 0.08 |
| 832585 | ESTs | 0.21 | 0.06 | 0.21 | |
| 620819 | transcription elongation factor A (SII) 1 | AI158848 | 0.24 | 0.07 | 0.25 |
| 831701 | ESTs | 0.2 | 0.09 | 0.25 | |
| 775253 | ESTs | 0.16 | 0.07 | 0.22 | |
| 334182 | Unknown | 0.24 | 0.06 | 0.21 | |
| 493675 | Riken cDNA 2700018N07 gene | Scd1 | 0.18 | 0.1 | 0.21 |
| 571367 | Riken cDNA 2410012F02 gene | 0.24 | 0.11 | 0.27 | |
| 463388 | Epoxide hydrolase 2, cytoplasmic | Ephx2 | 0.3 | 0.11 | 0.41 |
| 374030 | EST | 0.25 | 0.11 | 0.33 | |
| 1067881 | Fc receptor, IgG, low affinity III | Fcgr3 | 0.36 | 0.16 | 0.26 |
| 474184 | Expressed sequence AW554339 | 0.3 | 0.15 | 0.33 | |
| 579349 | Expressed sequence AI593221 | 2410127E18Rik | 0.29 | 0.18 | 0.23 |
| 874232 | Riken cDNA 1110025G12 gene | 1110025G12Rik | 0.33 | 0.19 | 0.56 |
| 891453 | Expressed sequence AI315208 | AI315208 | = | 0.2 | 0.16 |
| 1399595 | Riken cDNA 2810422B09 gene | 1810061M12Rik | 0.3 | 0.18 | 0.4 |
| 737745 | ESTs | 0.34 | 0.17 | 0.37 | |
| 876063 | BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3 | Bnip3 | 0.38 | 0.27 | 0.62 |
| 850642 | Epoxide hydrolase 2, cytoplasmic | Ephx2 | 0.18 | 0.22 | 0.44 |
| 1248105 | Expressed sequence AI595343 | AI595343 | 0.42 | 0.21 | 0.37 |
| 330661 | Mus musculus golli-interacting protein mRNA, complete cds | Nif3 | 0.66 | 0.21 | 0.22 |
| 1349720 | Apoptosis NIP3, Bcl-2-binding protein homolog (Nip3) mRNA | Bnip3 | 0.37 | 0.29 | 0.52 |
| 1067414 | Expressed sequence AI413399 | 1110001E17Rik | = | 0.24 | 0.52 |
| 832584 | ESTs, Weakly similar to STHM MOUSE STATHMIN [M. musculus] | 0.31 | 0.21 | 0.46 | |
| 876369 | Amyotrophic lateral sclerosis 2 (juvenile) homolog (human) | Als2 | 0.41 | 0.29 | 0.39 |
| 764542 | ESTs, Weakly similar to GPRY_mouse probable G protein-coupled receptor GPR34 [M. musculus] | Gpr43 | 0.49 | 0.24 | 0.43 |
| 1248075 | Transcription factor 1 | Tcf1 | 0.29 | 0.31 | 0.36 |
| 949592 | ESTs, Moderately similar to hypothetical protein [H. sapiens] | = | 0.32 | 0.22 | |
| 1195295 | Actinin α3 | Actn3 | = | 0.29 | 0.43 |
| 820307 | A kinase (PRKA) anchor protein (gravin) 12 | Akap12 | = | 0.31 | 0.08 |
| 864409 | Riken cDNA 1200013I08 gene | 1200013I08Rik | 0.47 | 0.33 | 0.39 |
| 947659 | Riken cDNA 2310016E22 gene | 2310016E22Rik | = | 0.33 | 0.37 |
| 1396547 | Myosin binding protein H | = | 0.25 | 0.45 | |
This list displays genes that are differentially expressed between mammary tumors (WntT) and hyperplastic mammary gland (WntH) from MMTV-Wnt-1 transgenic mice, and that are also differentially expressed between WntT and mammary tumors from MMTV-Neu transgenic mice (NeuT). Genes are sorted according to the average ratio of WntT versus WntH. A numeric ratio is displayed if the gene expression meets the criteria (statistical significance and fold cutoff) described in Table 2; otherwise, it is marked as '=', indicating that there is no significant difference between the two sets of samples in comparison. EST, expressed sequence tag; MMTV, mouse mammary tumor virus.