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. 2005 Oct 20;115(11):3057–3071. doi: 10.1172/JCI24792

Figure 2.

Figure 2

Treatment of TNBS-colitis by administration of NF-κB decoy ODNs. (A–D) TNBS-colitis was induced by i.r. administration of TNBS in ethanol. Mice were treated with NF-κB decoy ODNs (or scrambled ODNs) via an i.r. route (at 4 hours) or via an i.p. route (at 4, 24, and 48 hours). Data shown are representative of 3 independent experiments. (A) Body weight as a percent of starting weight. Data shown are mean values ± SD and derived from at least 7 mice per group. (B) Animal survival during the first 5 days after TNBS administration. (C) H&E staining of representative colon cross-sections on day 5 after TNBS administration. Magnification, ×5. (D) Histological scores shown are mean values ± SD from at least 7 mice per group. (E–H) TNBS-colitis was induced by i.r. administration of TNBS in ethanol. On day 5, mice with at least 20% body weight loss and not in recovery phase were pooled and divided into treatment groups. Mice were treated with NF-κB decoy ODNs (or scrambled ODNs) via an i.r. route (day 5) or via an i.p. route (days 5–7). Data shown are representative of 2 independent experiments. (E) Body weight as a percent of starting weight. Data shown are mean values ± SD from at least 7 mice per group. (F) Animal survival in percent until day 9 after TNBS administration. (G) H&E staining of representative colon cross-sections on day 9 after TNBS administration. Magnification, ×5. (H) Histological scores are shown as mean values ± SD from at least 7 mice per group. *P < 0.05.