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. 2005 Feb 24;113(6):675–679. doi: 10.1289/ehp.7633

Figure 4. BPA inhibits the effects of 17α -E2 on CA1 PSSD. In the absence of BPA, 17α -E2 induced an increase in synapse density of 0.463 synapses/μm3, a 65% increase above the mean synapse density in vehicle-injected controls. In the presence of BPA, the effect of the estrogen was reduced to an increase of 0.192 synapses/μm3, 39% above the level observed in animals treated with BPA alone. Two-way ANOVA: 17α -E2 effect, F = 237.3, df 1,8, p < 0.0001; BPA effect, F = 292.8, df 1,8, p < 0.0001; 17α -E2 × BPA interaction, F = 40.8, df 1,8, p = 0.0002. : *Significantly higher PSSD than in vehicle-treated rats, without BPA (Student t-test, p < 0.05). : **Significant inhibitory effect of BPA compared with animals given the same vehicle or 17α -E2 without BPA (Bonferroni-Dunn post hoc test, p < 0.05).

Figure 4