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The structure of mAb b12. The structure of Fab b12 as described in ref. 19 is shown with the CDRs presented in colors and labeled as belonging to the heavy (H) or light (L) chain. The long HCDR3 (H3) is clearly visible as an extended finger-like structure. Critical aromatic residues on the CDRs for binding to gp120 (19–21) are prominent.
