Fig. 6.

A model of mAbs 2F5 (56) and 4E10 (59) Fabs bound to their epitopes close to the virus membrane. The Fabs are shown as a solvent-accessible surface (gray) with their Cα trace from the heavy (blue) and light (cyan) embedded in the translucent structure. The CDRH3s of the antibodies are shown in purple. The MPER model structure (yellow) is based on connecting the actual structures of peptides observed in the corresponding crystal structures of the Fab–peptide complexes. The potential for simultaneous interaction of the antibody molecules with the viral membrane is illustrated.