Fig. 1.

Schematic illustration of AmPrβCD (A Left) in comparison with PA₆₃ channel (A Right) and its inhibitory action on PA₆₃-induced membrane conductance (B). Membrane in B contained ≈60 (PA₆₃)₇ channels. The downward arrow indicates the addition of AmPrβCD to the cis side of the membrane (side of PA addition). The dashed line shows zero current level. The temperature was 23°C and the applied voltage was +20 mV (potential at the cis side of the membrane was more positive). Diphytanoyl phosphatidylcholine planar lipid membranes were bathed by 0.1 M KCl/1 mM EDTA solution at pH 6.6. (Inset) Enlarged (×3) portion of the trace, showing steplike character.