Table 1. Summary of tested fusion proteins.
| Ligand | Target | ODC (N) | ODC plus AZ | SIP (N) | Siah (N) | E7 (C) | Fbx7 (C) | Ub1 (N) | Ub4 (N) | S5a (N) |
|---|---|---|---|---|---|---|---|---|---|---|
| TRAF6-C | TRAF6 | ↓ | ↓ | — | — | — | — | — | — | — |
| RANK-pep. | TRAF6 | — | ↓ | — | — | — | — | — | — | — |
| CD40CT | TRAF2 | — | — | nd | nd | nd | nd | nd | nd | — |
| I-TRAF | TRAF2 | — | — | — | nd | nd | nd | nd | nd | — |
| IKKα(LZ) | IKKα | — | — | — | nd | nd | nd | nd | nd | — |
| IKKβ(LZ) | IKKβ | ↓ | ↓ | — | nd | nd | nd | nd | nd | — |
| E7 | Rb | — | ↓ | — | — | nd | — | — | — | — |
| Caspase9(CARD) | Apaf1 | — | — | — | — | — | — | — | — | nd |
| Apaf1(CARD) | Caspase9 | nd | — | — | — | — | — | — | — | nd |
| FADD(DED) | Caspase8 | nd | — | — | — | — | — | — | — | nd |
| BAG-1 | HSP70 | — | — | nd | nd | nd | nd | nd | nd | nd |
| p21 | Cdk2 | ↓ | ↓ | nd | — | — | nd | nd | nd | nd |
| Success ratio | All targets | 3/12 | 5/12 | 0/9 | 0/7 | 0/6 | 0/6 | 0/6 | 0/6 | 0/7 |
N, N-terminal fusion; C, C-terminal fusion; nd, not done; ↓, decrease; —, no change.