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. 2025 Oct 27;17:2441–2457. doi: 10.2147/CMAR.S540752

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© 2025 Lv et al.

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Prediction of the downstream regulation mechanism of tRF5-23-GlyTCC-2 (A) Venn diagram evaluating the overlapping genes predicted by the miRanda and TargetScan databases. (B and C) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the potential target genes. The bar chart (B) and bubble chart (C) display the top significantly enriched pathways. The label “Sig pathway of DE gene” on the axes refers to “Significantly enriched pathways of differentially expressed genes” (the predicted target genes). The Rich Factor and P-value indicate the degree and statistical significance of the enrichment, respectively. (D) Gene Ontology (GO) functional enrichment analysis of the potential target genes. The bar chart shows the top significantly enriched terms across the three GO categories: Biological Process (BP), Molecular Function (MF), and Cellular Component (CC). The label “Sig Go terms of DE gene” on the axis refers to “Significantly enriched Gene Ontology terms of differentially expressed genes” (the predicted target genes). The Rich Factor and P-value indicate the degree and statistical significance of the enrichment, respectively.