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Role of IRF-4 in vivo. Age-matched wild-type (n = 7) and Irf4-/- (n = 4) mice were i.p. injected with ODN1668 (10 nmol) and d-GalN (20 mg). (a) The concentrations of serum IL-6, IL-12p40, and TNF-α were measured by ELISA. Results shown are the means (±SD) of serum samples. (b) The survival of these mice was monitored for 15 h.
