Table 5.

Overview of formulas and criteria for disproportionality analysis. a, number of reports containing both the target drugs and target adverse drug events; b, number of reports containing other adverse drug events of the target drugs; c, number of reports containing the target adverse drug events of other drugs; d, number of reports containing other drugs and other adverse drug events; N, the number of reports; ROR, reporting odds ratio; 95% CI, 95% confidence interval; PRR, proportional reporting ratio; χ², chi-squared; IC, information component; IC025, the lower limit of 95% CI of the IC; E (IC), the IC expectations; V(IC), the variance of IC; MGPS, multi-item gamma Poisson shrinker; EBGM, empirical bayesian geometric mean; EBGM05, the lower limit of 95% CI of EBGM.

Algorithms	Formulas	Criteria
ROR	ROR = ad/bc	Lower limit of 95% CI > 1, N ≥ 3
	95%CI = eln(ROR)±1.96(1/a+1/b+1/c+1/d)^0.5
PRR	PRR = [a(c + d)]/[c(a + b)]	PRR ≥ 2, χ2 ≥ 4, N ≥ 3
	χ2 = [(ad-bc)^2](a + b + c + d)/[(a + b)(c + d)(a + c)(b + d)]
BCPNN	IC = log2a(a + b + c + d)/[(a + c)(a + b)]	IC025 > 0
	95%CI = E(IC) ± 2[V(IC)]^0.5
MGPS	EBGM = a(a + b + c + d)/[(a + c)(a + b)]	EBGM05 > 2
	95%CI = eln(EBGM)±1.96(1/a+1/b+1/c+1/d)^0.5