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Fig. 6. Model for the role of Ser259 in Raf-1 activation. The steps designated in the figure are: (1) Raf-1 membrane translocation and Ras binding. (2) Derepression by PP2A-mediated dephosphorylation of Ser259. (3) Phosphorylation of Raf-1 by activating kinases on Ser338 and Tyr341. (4) Phosphorylation of the substrate MEK. (5) Re-phosphorylation of Ser259, dephosphorylation of activating sites and transition into a quiescent state. See text for details.
