Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Oct 13;33(18):5861–5867. doi: 10.1093/nar/gki894

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2005. Published by Oxford University Press. All rights reserved

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

PMC Copyright notice

ROC plots comparing functional site prediction using the sequence and energy based methods alone and in combination. The horizontal axis is the frequency of false positives (non-functional residues predicted to be functional) and the vertical axis the frequency of true positives (functional residues predicted to be functional). For the same false positive level, adding in either the natural/designed PSSM difference or the natural/optimal energy gap to the SCORECONS method increases the frequency for true positives. The combination of the three measures has the best performance.