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. 2005 Oct 19;33(18):5945–5953. doi: 10.1093/nar/gki906

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Quantitative analysis of the binding of vTopIB to DNA. (a) Filament length distribution for three different data sets. For each set ω was estimated using the ML method resulting in ω = 5.6 ± 1.4 × 10³ for DNA saturation θ = 0.07 (closed squares); ω = 9.1 ± 1.7 × 10³ for DNA saturation θ = 0.18 (closed circles); and ω = 8.8 ± 1.8 × 10³ for DNA saturation θ = 0.23 (closed triangles). The solid lines in (a) are plots of Equation 1 using the obtained ω. (b) Fractional DNA saturation as a function of total vTopIB concentration. The fit of Equation 4 to these data using n = 18, N = 2743 and ω = 7.7 ± 1.1 × 10³ yielded a value for K^* = 4.0 ± 0.4 × 10⁴ M⁻¹.