Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Fig. 9. Model of NF1/X repression of PDGF-A promoter activity. NF1/X physically interacts with Sp1 (which regulates basal and inducible PDGF-A transcription) and prevents Sp1 occupancy of the PDGF-A promoter, shutting down gene expression as a consequence. The influence of NF1/X on other promoter-bound nuclear factors is presently unclear. BTM, basal transcriptional machinery.
