Table 3.
Associations of high myopia and the systemic inflammatory parameters.
| Factors | Univariate analysis | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Usual systemic inflammatory parameters | ||||||
| WBC (103/uL) | 1.030 (0.941, 1.127) | .517 | 0.200 (0.063, 0.628) | .007 | 0.242 (0.070, 0.843) | .027 |
| Neu (103/uL) | 1.031 (0.929, 1.144) | .555 | 5.000 (1.534, 16.297) | .008 | 4.052 (1.127,14.559) | .033 |
| Lym (103/uL) | 1.160 (0.823, 1.634) | .674 | 6.269 (1.857, 21.161) | .004 | 4.989 (1.287, 19.337) | .021 |
| Mono (103/uL) | 1.104 (0.285, 4.275) | .884 | 4.653 (0.858, 25.249) | .074 | 6.204 (0.918, 41.930) | .061 |
| Plt (103/uL) | 1.001 (0.997, 1.006) | .569 | 1.001 (0.995, 1.006) | .761 | 1.001 (0.996, 1.006) | .723 |
| CRP (mg/dl) | 1.315 (1.069, 1.618) | .010 | 1.320 (1.020, 1.709) | .036 | 1.202 (0.880, 1.643) | .241 |
| Four systemic inflammatory markers | ||||||
| NLR | 0.969 (0.803, 1.170) | .739 | 0.644 (0.424, 0.977) | .039 | 0.621 (0.411, 0.938) | .025 |
| LMR | 1.031 (0.891, 1.194) | .674 | 0.964 (0.792, 1.175) | .715 | 0.949 (0.657, 1.371) | .775 |
| PLR | 0.999 (0.803, 1.170) | .739 | 0.994 (0.987, 1.002) | .149 | 0.903 (0.717, 1.136) | .376 |
| SII | 1.001 (1.000, 1.001) | .492 | 1.002 (1.000, 1.003) | .013 | 1.002 (1.000, 1.003) | .011 |
| Significant covariate | ||||||
| Gender (female) | 1.778 (1.209, 2.617) | .004 | – | – | 1.712 (1.197,2.448) | .004 |
| Education | ||||||
| <9th grade | Ref | – | – | Ref | – | |
| 9–11th grade | 0.959 (0.506, 1.816) | .896 | – | – | 0.971 (0.502, 1.878) | .928 |
| High school Grade | 0.844 (0.345, 2.063) | .706 | – | – | 0874 (0.367, 2.081) | .756 |
| College or above | 2.826 (1.721, 4.639) | .004 | – | – | 2.806 (1.400, 5.627) | .005 |
Bold values represent significant differences.
Model 1: multivariate logistic analysis without adjustments.
Model 2: multivariate logistic analysis adjusted for age, gender, body mass index, poverty-to-income ratio, education level, diabetes, hypertension, and asthma.
CI = confidence interval, CRP = C-reactive protein, LMR = lymphocyte-to-monocyte ratio, Lym = lymphocytes, Mono = monocytes, Neu = neutrophils, NLR = neutrophil-to-lymphocyte, PLR = platelet-to-lymphocyte ratio, Plt = platelets, SII = systemic immune-inflammation index, WBC = white blood cells counts.