Table 3. List of reports on chemical structure modifications of xanthones (chemical structures were drawn using PubChem and Mestrenova).

Class	Parent compound	Derivative(s)	Outcome	Ref
Prenylated xanthones			Increased lipophilicity	216
			Improved solubility
Tetraoxygenated xanthones			Wider spectrum, more selective antibacterial activity	42 and 218
			Lower toxicity; antibacterial activity	42 and 219
			Wider spectrum, antifungal activity
			Rapid bactericidal effect	220
			Lower toxicity
			Avoidance of induced resistance
			Higher selectivity
			Rapid bactericidal effect	220
			Lower toxicity
			Avoidance of induced resistance
			Higher selectivity
			Higher solubility	69
			Higher antiangiogenic and anticancer activities	69
			Higher bioavailability
Miscellaneous xanthones			Higher potency	193
			Higher potency	193
			Higher potency	193
Prenylated xanthones			Higher potency	197
			Higher selectivity
			Higher potency	197
			Higher selectivity
			Higher potency	198 and 199
			Higher selectivity
Xanthone glycoside			Higher lipid solubility	211
			Better bioavailability
			More potent hypoglycemic effect
			Higher lipid solubility	211
			Better bioavailability
			More potent hypoglycemic effect
			Higher lipid solubility	211
			Better bioavailability
			More potent hypoglycemic effect
			Better solubility and bioavailability	214, 215 and 221
			Broader biological effects
			Better solubility and bioavailability	221
			More potent antitussive effect