TABLE 3.
Association of ESBLs and carbapenemases with final MIC levels to cefiderocol
| Cefiderocol MIC | ||||||||
|---|---|---|---|---|---|---|---|---|
| Carbapenemases | ESBLsa | No | 0.125 | 0.25 | 0.5 | 1 | 2 | 4 |
| ---b | --- | 7 | 2 | 5 | ||||
| NDM | --- | 1 | 1 | |||||
| OXA-23G | --- | 8 | 1 | 5 | 2 | |||
| OXA-24G | --- | 71 | 3 | 5 | 16 | 31 | 16 | |
| OXA-23G | GESc | 1 | 1 | |||||
| OXA-24G | VEB | 3 | 1 | 1 | 1 | |||
| OXA-24G | PER | 1 | 1 | |||||
| OXA-24G + OXA-23G | --- | 1 | 1 | |||||
| OXA-24G + OXA-48G | --- | 1 | 1 | |||||
| OXA-24G + NDM | --- | 1 | 1 | |||||
a
ESBLs, extended-spectrum β-lactamases.
b
The lack of carbapenemases and/or ESBLs is noted by hyphens.
c
Although classified as ESBL, in the absence of a full-gene amplification and sequencing, it cannot be definitively determined as an ESBL or carbapenemase.