TABLE 11.
Pattern of ParC amino acid substitutions detected in fluoroquinolone-resistant MRSA and MSSA clinical isolates from blood culture
| Group | Pattern of amino acid substitutions in ParC |
Total n = 63 (100) |
MRSA n = 63 (100) |
MSSA n = 3 (100) |
MIC level (μg/mL) | |
|---|---|---|---|---|---|---|
| Ciprofloxacin min-max (median) |
Levofloxacin min-max (median) |
|||||
| A | S80F | 43 (68) | 41 (68) | 2 (67) | 2–512 (64) | 1–256 (16) |
| B | S80F + E84K | 6 (10) | 6 (10) | 0 (0) | 64–512 (384) | 16–512 (512) |
| C | S80Y | 4 (6) | 4 (7) | 0 (0) | 16–256 (48) | 4–16 (10) |
| D | S80Y + E84G | 4 (6) | 4 (7) | 0 (0) | 256–1,024 (640) | 32 (32) |
| E | R20D + S80F | 1 (2) | 1 (2) | 0 (0) | 128 (128) | 64 (64) |
| F | S80F + E84K + I195M | 1 (2) | 1 (2) | 0 (0) | 512 (512) | 512 (512) |
| G | S80F + E84K + N203I + Q204H | 1 (2) | 1 (2) | 0 (0) | 64 (64) | 512 (512) |
| H | S80F + P153A | 1 (2) | 1 (2) | 0 (0) | 128 (128) | 16 (16) |
| I | NDa | 2 (3) | 1 (2) | 1 (33) | 1–64 (32.5) | 0.5–256 (128.25) |
| Total | 63 (100) | 60 (100) | 3 (100) | |||
a
ND, not detected.