TABLE 5.
Amino acid substitutions detected in the QRDR, including GyrA, GyrB, ParC, and ParE in fluoroquinolone-resistant MRSA clinical isolatesa
| Strain | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Region | |||||||||||||||
| GyrA | S84L | S84L | S84L | S84L | S84L | S84L | S84L | S84L | S84L | S84L | S84L | S84L | S84L | S84L | S84L |
| M121C | M121C | I131S | S85P | S85P | E88K | I175M | S85P | M121C | L167S | N182I | |||||
| I175M | D151* | M121C | I175M | ||||||||||||
| L188Q | L188* | D151M | N182I | ||||||||||||
| I175M | |||||||||||||||
| GyrB | NDb | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| ParC | S80F | S80F | S80F | S80F | S80F | S80F | S80F | S80F | S80F | S80F | S80F | S80F | S80Y | S80Y | S80F |
| E84K | E84K | E84K | E84K | ||||||||||||
| N203I | |||||||||||||||
| Q204H | |||||||||||||||
| ParE | P451S | ND | N402T | ND | P451S | ND | ND | ND | ND | ND | P451S | ND | ND | ND | ND |
| P451S |
a
"*” indicates stop codon.
b
ND, not detected.