Table 4.

Subgroup analyses: hazard ratios for overall survival (CCR) following treatment in DKG-certified ovarian cancer centers

Variable	Category	Univariable Cox regression				Multivariable Cox regressiona
		p-value	HR	lower CI	upper CI	p-value	HR	lower CI	upper CI
Stage group	I-IV + X	0.001	0.848	0.767	0.937	0.490	0.964	0.867	1.071
	I-IV - X	0.022	0.879	0.788	0.982	0.539	0.965	0.861	1.082
	I-III	0.009	0.820	0.706	0.951	0.014	0.825	0.708	0.961
UICC stage	I	0.011	0.540	0.335	0.870	0.087	0.650	0.397	1.064
	II	0.214	0.661	0.344	1.270	0.093	0.553	0.278	1.103
	III	0.124	0.881	0.749	1.035	0.093	0.866	0.733	1.024
	IV	0.289	0.915	0.777	1.078	0.064	1.180	0.990	1.407
	X/ns	0.966	0.994	0.769	1.286	0.807	1.034	0.790	1.354
Age at diagnosis (years)	0–49	0.069	0.666	0.430	1.032	0.141	0.712	0.452	1.120
	50–59	0.515	0.915	0.701	1.195	0.590	1.079	0.818	1.424
	60–69	0.324	0.899	0.728	1.111	0.067	0.813	0.651	1.015
	70–79	0.466	0.940	0.797	1.109	0.814	1.021	0.858	1.216
	80+	0.695	1.046	0.837	1.307	0.405	1.107	0.871	1.407
Year of diagnosis	2009–11	0.016	0.798	0.664	0.958	0.607	0.952	0.789	1.149
	2012–14	0.041	0.845	0.719	0.993	0.361	0.926	0.785	1.092
	2015–17	0.111	0.850	0.697	1.038	0.401	1.091	0.890	1.338
Grading	G1	0.219	0.554	0.216	1.421	0.840	1.118	0.378	3.303
	G2	0.004	0.680	0.525	0.881	0.172	0.830	0.634	1.085
	G3/4	0.186	0.918	0.809	1.042	0.586	0.964	0.846	1.099
	GX/ns	0.246	0.870	0.687	1.101	0.369	1.121	0.873	1.440
Lymphatic invasion	L0	0.039	0.790	0.632	0.988	0.104	0.825	0.654	1.041
	L1	0.521	1.058	0.890	1.257	0.522	1.061	0.886	1.271
	LX/ns	0.370	0.934	0.803	1.085	0.958	0.996	0.850	1.166
Vein invasion	V0	0.318	0.922	0.786	1.081	0.273	0.912	0.774	1.075
	V1/2	0.748	0.954	0.718	1.269	0.612	1.085	0.793	1.484
	VX/ns	0.319	0.928	0.802	1.075	0.872	0.987	0.847	1.152

^aadjusted for age at diagnosis, year of diagnosis, UICC stage, grading, lymphatic, and venous invasion

p = log-rank p-value, HR = hazard ratio, CI Confidence interval, X not determinable, ns not specified