Table 2. Inhibition of NO-production in LPS-stimulated RAW 264.7 cells and cytotoxicity against human cancer cells of isolated compounds.
| Compound | IC50a (μM) ± SD | ||||
|---|---|---|---|---|---|
| Inhibition of NO-production | Cytotoxicity | ||||
| A549 | Hep-G2 | MCF-7 | HEK-293A | ||
| 1 | NA | 31.25 ± 1.21 | 23.82 ± 1.21 | 27.56 ± 1.15 | 24.75 ± 0.95 |
| 2 | NA | 31.09 ± 1.06 | 19.05 ± 0.47 | 22.15 ± 0.93 | 24.46 ± 0.67 |
| 3 | 95.71 ± 3.39 | 47.78 ± 3.85 | 25.63 ± 2.10 | 29.22 ± 1.34 | 34.08 ± 2.70 |
| 4 | >100 | >100 | >100 | >100 | NT |
| 5 | >100 | >100 | >100 | >100 | NT |
| 6 | >100 | >100 | >100 | >100 | NT |
| 7 | 79.94 ± 1.37 | 39.32 ± 1.29 | 22.37 ± 1.01 | 27.38 ± 1.19 | 30.08 ± 1.25 |
| 8 | 71.85 ± 2.41 | 34.05 ± 1.70 | 19.58 ± 1.93 | 27.01 ± 2.09 | 22.82 ± 1.09 |
| 10 | >100 | >100 | 72.84 ± 3.62 | 86.59 ± 4.66 | 97.19 ± 3.85 |
| 11 | >100 | 42.37 ± 2.34 | 32.52 ± 2.28 | 37.59 ± 2.31 | 19.46 ± 1.55 |
| 12 | >100 | >100 | >100 | >100 | NT |
| 15 | NA | 14.28 ± 0.36 | 10.65 ± 0.40 | 12.19 ± 0.42 | 12.52 ± 0.37 |
| 16 | NA | 40.12 ± 0.87 | 29.98 ± 1.35 | 36.18 ± 1.18 | 43.22 ± 2.28 |
| 17 | >100 | >100 | 80.74 ± 3.59 | 99.3 ± 6.83 | 70.74 ± 4.44 |
| Dexamethasoneb | 13.09 ± 1.13 | — | — | — | — |
| Ellipticineb | — | 1.71 ± 0.08 | 1.42 ± 0.08 | 1.54 ± 0.04 | 1.34 ± 0.08 |
a
The half-maximal inhibitory concentration.
b
Positive control, NA: not available, NT: not tested.