Table 2.

Mendelian randomization results in the replication cohort.

Genes	IBS replication GWAS cohort
	SNPs	OR (95% CI)	IVW p val	MR-Egger intercept	MR-Egger p val
P2RY14	9	1.11 (1.04–1.17)	5.86e−04	0.005	0.614
SLC5A6	12	1.10 (1.05–1.15)	3.22e−05	−0.001	0.929
ATRAID	12	0.89 (0.85–0.93)	2.23e−06	−0.005	0.681
IL1RL1	11	0.87 (0.80–0.94)	2.18e−04	−0.003	0.820