Table 2. Univariate and multivariable Cox regression analysis of clinical and imaging predictors for MACE in training cohort.
| Variables | Univariate analysis | Multivariable analysis 1 | Multivariable analysis 2 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |||
| Age | 1.05 | 1.01–1.08 | 0.005 | 1.05 | 1.01–1.09 | 0.008 | 1.06 | 1.02–1.10 | 0.005 | ||
| Females | 1.38 | 0.68–2.83 | 0.377 | ||||||||
| BMI | 0.98 | 0.90–1.08 | 0.699 | ||||||||
| Hypertension history | 0.95 | 0.47–1.89 | 0.877 | ||||||||
| Diabetes history | 2.15 | 1.13–4.08 | 0.019 | 2.12 | 1.11–4.07 | 0.023 | 2.03 | 1.06–3.90 | 0.034 | ||
| Dyslipidemia history | 1.04 | 0.56–1.93 | 0.910 | ||||||||
| CAD history | 2.25 | 1.07–4.72 | 0.033 | 2.08 | 0.98–4.39 | 0.056 | 2.00 | 0.94–4.24 | 0.072 | ||
| Smoking history | 0.77 | 0.41–1.43 | 0.402 | ||||||||
| AICVD history | 1.08 | 0.55–2.13 | 0.818 | ||||||||
| Family history of cardiovascular disease | 0.98 | 0.51–1.90 | 0.959 | ||||||||
| Systolic BP | 1.01 | 0.99–1.02 | 0.521 | ||||||||
| Diastolic BP | 0.99 | 0.96–1.02 | 0.439 | ||||||||
| NIHSS | 0.97 | 0.87–1.08 | 0.616 | ||||||||
| Water swallow test | 0.51 | 0.22–1.22 | 0.132 | ||||||||
| Glycated hemoglobin | 1.07 | 0.90–1.28 | 0.432 | ||||||||
| Fast glucose | 1.10 | 1.00–1.22 | 0.047 | 1.04 | 0.92–1.18 | 0.529 | 1.03 | 0.91–1.17 | 0.631 | ||
| Triglyceride | 0.86 | 0.58–1.28 | 0.465 | ||||||||
| TC | 0.91 | 0.66–1.26 | 0.588 | ||||||||
| HDL-C | 0.44 | 0.12–1.64 | 0.219 | ||||||||
| LDL-C | 0.95 | 0.66–1.37 | 0.788 | ||||||||
| Homocysteine | 0.99 | 0.95–1.02 | 0.498 | ||||||||
| Fibrinogen | 0.92 | 0.66–1.28 | 0.636 | ||||||||
| D-dimer | 1.04 | 0.98–1.11 | 0.213 | ||||||||
| TOAST | 1.60 | 0.74–3.47 | 0.234 | ||||||||
| CT-FFR ≤0.80 | 4.30 | 1.32–13.94 | 0.015 | 3.52 | 1.08–11.48 | 0.037 | |||||
| CAS | 1.20 | 1.09–1.33 | <0.001 | 1.22 | 1.10–1.36 | <0.001 | 1.21 | 1.08–1.35 | 0.001 | ||
| Significant coronary stenosis | 1.24 | 0.59–2.60 | 0.576 | ||||||||
| CACS (level) | 1.62 | 1.14–2.31 | 0.007 | 1.25 | 0.86–1.82 | 0.244 | 1.10 | 0.74–1.62 | 0.636 | ||
AICVD, acute ischemic cerebrovascular disease; BMI, body mass index; BP, blood pressure; CACS, coronary artery calcium score; CAD, coronary artery disease; CAS, cerebral atherosclerosis score; CI, confidence interval; CT-FFR, coronary computed tomography-derived fractional flow reserve; HDL-C, high-density lipoprotein cholesterol; HR, hazard ratio; LDL-C, low-density lipoprotein cholesterol; NIHSS, National Institutes of Health Stroke Scale; TC, total cholesterol; TOAST, Trial of ORG 10172 in Acute Stroke Treatment.