Table 2. MG-MID (μM) values of compounds 4a–4d, 6a–6c, 6f, 6h, and 6i on a subpanel of cancer cell lines.
| Subpanel | Compound ID | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 4a | 4b | 4c | 4d | 6a | 6b | 6c | 6f | 6h | 6i | |
| MG-MIDa (μM) | ||||||||||
| Leukemia | 1.657 | 2.220 | 0.996 | 2.414 | 7.822 | 7.445 | 1.530 | 2.067 | 1.910 | 5.415 |
| Non-small cell lung cancer | 5.240 | 3.483 | 2.519 | 6.940 | 15.856 | 28.275 | 8.471 | 5.267 | 5.947 | 8.102 |
| Colon cancer | 3.537 | 3.024 | 1.405 | 3.487 | 12.607 | 14.736 | 4.919 | 3.336 | 3.087 | 7.397 |
| CNS cancer | 5.027 | 4.210 | 2.773 | 5.698 | 11.365 | 16.865 | 3.408 | 2.940 | 4.197 | 5.698 |
| Melanoma | 4.089 | 3.684 | 1.721 | 5.939 | 13.101 | 17.893 | 3.564 | 4.680 | 3.667 | 5.643 |
| Ovarian cancer | 5.756 | 3.271 | 3.403 | 6.369 | 13.694 | 23.720 | 8.856 | 6.349 | 9.867 | 8.533 |
| Renal cancer | 5.966 | 3.560 | 1.983 | 8.907 | 14.167 | 33.783 | 8.345 | 5.510 | 4.876 | 12.126 |
| Prostate cancer | 4.060 | 6.900 | 1.940 | 3.570 | 17.400 | 61.300 | 12.400 | 6.200 | 2.415 | 10.685 |
| Breast cancer | 3.478 | 2.378 | 1.621 | 4.458 | 10.427 | 15.775 | 1.698 | 2.167 | 2.855 | 5.475 |
| Full panel MG-MIDb | 4.312 | 3.637 | 2.040 | 5.309 | 12.938 | 24.421 | 5.910 | 4.279 | 4.313 | 7.675 |
a
Median value of GI50 (μM) calculated according to the data obtained from NCI's tumor cell screen.
b
Full panel mean graph midpoint (MG-MID) is the average sensitivity of all cell lines towards the tested compounds.