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. 2025 Nov 7. Online ahead of print. doi: 10.1039/d5md00787a

Table 4. VEGFR-2 kinase inhibitory activity of compounds 4a–4d, 6a–6c, 6f, 6h, 6i and sorafenib.

Compound ID VEGFR-2 kinase Compound ID VEGFR-2 kinase
IC50 (μM) IC50 (μM)
4a 1.176 6a 0.189
4b 0.319 6b 0.371
4c 0.144 6c 0.406
4d 0.105 6f 0.172
Sorafenib 0.081 6h 0.561
6i 0.072