1. Cytotoxic Effect of the CH-1 on HPV18-Positive Cervical Cancer Cells under Different Conditions .
| IC50 μg/mL (μM) |
|||
|---|---|---|---|
| condition evaluated | parameter | HeLa | Ca Ski |
| evaluation of the cytotoxic effect at 4 and 37 °C | 37 °C | 34 (16) | 30 (14) |
| 4 °C | 76 (36) | 88 (42) | |
| evaluation of the cytotoxic effect in cells depleted in ATP | untreated | 57 (27) | 101 (48) |
| sodium azide | 65 (31) | 86 (41) | |
| evaluation of the cytotoxic effect in the presence of endocytosis inhibitors | untreated | 57 (27) | 101 (48) |
| nystatin | 56 (26.5) | 74 (36) | |
| chlorpromazine | 55 (26) | 88 (42) | |
| cell viability vs time (IC50) | 2 h | 54 (26) | - |
| 24 | 75 (36) | - | |
| 48 | 104 (50) | - | |
| cytotoxic effect of the rhodamine B-labeled chimera in HeLa cells | CH-1 | 34 (16) | - |
| RhB-CH-1 | 16 (7) | - | |
a
- Indicates that assays were not performed on Ca Ski cells.