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Fig. 1. Frequency histograms showing the pI values, estimated using the ProtParam tool (http://www.expasy.ch/tools/protparam.html) (at 0.25 unit intervals) of nuclear proteins that have been reported to concentrate in different nuclear compartments (splicing speckles, nucleolus, nuclear periphery, and chromatin-associated). A selection of proteins that appear to be diffusely localized through the nucleoplasm are included for comparison.
