Skip to main content
. 2025 Nov 7;25:3839. doi: 10.1186/s12889-025-24915-2

Table 2.

Association of muscle strength with incident depressive symptoms

No. of cases/ participants Model 1 Model 2 Model 3
HR (95% CI) RD HR (95% CI) RD HR (95% CI) RD
Handgrip strength, Kg 2707/6961 0.98 (0.97–0.98) 0.98 (0.97–0.99) 0.98 (0.98–0.99)
 First quantile (< 27.5) 833/1741 Reference Reference Reference
 Second quantile (27.5–34.0) 736/1740 0.80 (0.72–0.88) -0.08 0.82 (0.74–0.98) -0.07 0.82 (0.74–0.91) -0.07
 Third quantile (34.0–42.0) 615/1740 0.63 (0.57–0.70) -0.15 0.70 (0.62–0.79) -0.13 0.71 (0.63–0.80) -0.13
 Fourth quantile ( > = 42.0) 523/1740 0.51 (0.45–0.56) -0.22 0.59 (0.51–0.68) -0.19 0.61 (0.53–0.71) -0.18
 P for trend < 0.001 < 0.001 < 0.001
Time of 5TSTS, seconds 2707/6961 1.03 (1.02–1.03) 1.02 (1.01–1.03) 1.02 (1.01–1.03)
 First quantile (< 7.8) 591/1741 Reference Reference Reference
 Second quantile (7.8–9.5) 661/1740 1.15 (1.03–1.29) 0.04 1.10 (0.98–1.22) 0.03 1.09 (0.97–1.21) 0.03
 Third quantile (9.5–11.7) 698/1740 1.27 (1.14–1.42) 0.07 1.18 (1.05–1.31) 0.06 1.17 (1.04–1.30) 0.05
 Fourth quantile ( > = 11.7) 757/1740 1.47 (1.32–1.64) 0.12 1.32 (1.18–1.47) 0.10 1.30 (1.16–1.45) 0.09
 P for trend < 0.001 < 0.001 < 0.001

CI confidence interval, HR hazard ratio, RD risk difference, 5TSTS Five Times Sit to Stand Test; Model 1 was the basic model. Mode 2 was adjusted for age, gender, education, income, marriage; Model 3 was further adjusted for smoke, alcohol use, obesity, hypertension, diabetes, dyslipidemia, number of comorbidities, number of child, weight loss, and mild cognitive decline