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. 2002 May 1;21(9):2263–2271. doi: 10.1093/emboj/21.9.2263

Table II. Summary of functions proposed for different phosphorylation sites on FKHR.

Phosphorylation site Putative upstream kinase Proposed function
Thr24 PKB/SGK 14-3-3 binding (Brunet et al., 1999; Rena et al., 2001), perhaps to block DNA binding (Cahill et al., 2001) and/or to promote cytoplasmic retention (Brunet et al., 1999)
Ser256 PKB/SGK Inhibition of transactivation (Guo et al., 1999), masking of adjacent nuclear localization signal (Brownawell et al., 2001; Rena et al., 2001)
Ser319 PKB/SGK Regulation of nuclear export (this study)
Ser322 and Ser325 CK1 Regulation of nuclear export (this study)
Ser329 DYRK Mutation of this constitutive site increases transactivation, at least in part by increasing basal nuclear localization (Woods et al., 2001b)