Thr24 |
PKB/SGK |
14-3-3 binding (Brunet et al., 1999; Rena et al., 2001), perhaps to block DNA binding (Cahill et al., 2001) and/or to promote cytoplasmic retention (Brunet et al., 1999) |
Ser256 |
PKB/SGK |
Inhibition of transactivation (Guo et al., 1999), masking of adjacent nuclear localization signal (Brownawell et al., 2001; Rena et al., 2001) |
Ser319 |
PKB/SGK |
Regulation of nuclear export (this study) |
Ser322 and Ser325 |
CK1 |
Regulation of nuclear export (this study) |
Ser329 |
DYRK |
Mutation of this constitutive site increases transactivation, at least in part by increasing basal nuclear localization (Woods et al., 2001b) |