Table 2.
Natural compounds targeting highly virulent PEDV.
| Natural compounds | Inhibit PEDV in cells | Effective in pigs | Target | References |
|---|---|---|---|---|
| Flavonol | PEDV-YN145 | No report | Interacts with PEDV Mpro. | Liang et al. (2024) |
| Tomatidine | PEDV MS, YZ, SH, and CV777 | No report | Inhibition of 3CLpro activity. | Wang et al. (2020) |
| Wogonin | PEDV AH2012/12 | No report | Exerts an inhibitory effect on Mpro. | Wang J. et al. (2023) |
| Licorice extract | PEDV HM2017 | Against PEDV HM2017 infection in piglets. | 1. Interfering with the PEDV N protein, ORF3 mRNA, and M protein 2. Inhibiting the PI3K signaling pathway |
Yang et al. (2023) |
| Buddlejasaponin IVb | PEDV AH-2018-HF1 | Relieving clinical symptoms in pigs. | Inhibits the NF-κB signaling pathway. | Sun et al. (2022) |
| Hypericum japonicum extract | PEDV-CV777 and PEDV-G2 | Improving intestinal pathology in piglets | Interfering with interaction between the N protein and p53. | Rao et al. (2023) |
| Puerarin | PEDV Yunnan province strain | Reduction of PEDV impact on growth performance in piglets. | Regulating the IFN and NF-κB signaling pathways. | Wu et al. (2020) |
| Aloe extract | PEDV GDS01 | Protects newborn piglets from PEDV variant GDS01 infection | Blocking the transcription of viral N genes. | Xu Z. et al. (2020) |