Table 5.
Univariate and multivariate Cox regression analyses for predictors of recurrence
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (years) | 0.96 (0.93–1.00) | 0.069 | 0.94 (0.90–0.99) | 0.017 |
| Tumor subtype | ||||
| HR (+)/HER2 (-) | Reference | Reference | ||
| HR (+)/HER2 (+) | 0.46 (0.15–1.37) | 0.161 | 0.40 (0.12–1.39) | 0.150 |
| HR (-)/HER2 (+) | 0.93 (0.31–2.78) | 0.890 | 1.22 (0.34–4.30) | 0.761 |
| Triple negative | 0.48 (0.14–1.66) | 0.249 | 0.57 (0.15–2.16) | 0.413 |
| Ki-67 index | ||||
| < 20% | Reference | Reference | ||
| ≥ 20% | 0.86 (0.33–2.24) | 0.757 | 1.03 (0.35–2.99) | 0.963 |
| Clinical nodal status | ||||
| cN0 | Reference | Reference | ||
| cN1 | 0.85 (0.39–1.83) | 0.675 | 0.56 (0.24–1.28) | 0.168 |
| Axillary surgery | ||||
| SLNB | Reference | Reference | ||
| ALND | 1.36 (0.62–2.98) | 0.436 | 1.84 (0.73–4.62) | 0.193 |
| Pathologic complete response (pCR) | ||||
| No | Reference | Reference | ||
| Yes | 0.71 (0.30–1.68) | 0.434 | 1.16 (0.41–3.27) | 0.785 |
Abbreviations:HR Hazard ratio, CI Confidence interval, SLNB Sentinel lymph node biopsy, ALND Axillary lymph node dissection, pCR Pathologic complete response