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. 2025 Nov 10;26(6):bbaf586. doi: 10.1093/bib/bbaf586

Figure 1.

Flowchart illustrating the ProjectSVR pipeline showing input of UMAP embeddings and gene set scores, SVR model training, and mapping of query data with KNN-based cell label transfer.

Workflow of ProjectSVR. (a) The ProjectSVR takes integrated embeddings (e.g. UMAP) and gene set scores calculated via the UCell algorithm as inputs. (b) Then a regression model is fitted by supported vector regression (SVR). (c) For mapping, the query count matrix is transformed into signature scores, and the trained models predict query embeddings. Final predictions are aggregated via median. Cell type labels are transferred using a k-nearest neighbors (KNN) classifier.