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. 2025 Nov 10;26(6):bbaf586. doi: 10.1093/bib/bbaf586

Figure 4.

UMAP, dot, and density plots showing projection of decidual immune cells from RPL and control patients onto a maternal-fetal reference atlas and comparison of cell-type distributions.

Projection analysis of decidual immune cells between recurrent pregnancy loss (RPL) patients and healthy controls. (a) UMAP of maternal-fetal interface atlas, colored by cell type and tissue source. (b) Projection of decidual cells (query) from RPL patients and controls onto reference. Grey = reference, colors = manually annotated query cells. (see also Fig. S6). (c) Dot plot comparing true cell labels (columns), defined in (b), to predicted cell labels (rows) via k-NN label transfer using ProjectSVR. The dot size represents the frequency of predicted labels in each true label (the sum of rows is normalized to 1). (d) 2D density plot showing the projection of cells highly expressing heat shock proteins (HSP+ cells) onto the reference. Each dot represents a reference cell, colored by reference cell type. (e) Density of the predicted decidual NK (dNK) cells from controls and RPL patients mapped to dNK reference. (f) The distribution of dNK cells from controls and RPL patients corresponding to panel (e).