Table 2.

Stratified analysis: effect of study and test characteristics on summary diagnostic odds ratios

Subgroup (Number of studies)		Summary DOR (95% CI)
Study design	Case-control (24)	134.4 (65.2 – 213.1)
	Cross-sectional (60)	171.1 (106.7 – 274.2)
Blinding	Single or double blinded (29)	90.2 (46.2 – 176.2)
	Unblinded or NR (55)	221.2 (137.7 – 355.2)
DNA extraction method	Chemical (55)	153.7 (90.1 – 262.4)
	Physical (29)	171.7 (96.2 – 306.6)
Amplification method	PCR/multiplex (68)	139.3 (89.2 – 217.7)
	Nested PCR (16)	266.6 (140.8 – 504.6)
Target sequence	IS6110 (54)	236.1 (152.9 – 364.6)
	Other target (30)	77.4 (38.2 – 156.9)
Detection method	Probe (49)	130.6 (78.4 – 217.6)
	Gel-UV (35)	215.4 (115.1 – 403.2)
Sputum smear status	Pos/Both/NR (78)	161.5 (107.5 – 242.6)
	Negative (6)	128.6 (33.4 – 495.1)