Fig. 1. Computer-predicted two-dimensional structures of human box C/D–H/ACA snoRNAs. The evolutionarily conserved box C, D, H, ACA and the putative box C′ and D′ sequence motifs are boxed. The structure of the U85 snoRNA has been adopted from Jády and Kiss (2001). The genomic copies of the U85 and U89 snoRNAs are in the fourth and sixth introns of the structural maintenance of chromatin (D63880) and the B cell-associated protein (U75511) genes, respectively. The U87 and U88 snoRNAs are encoded within the ninth and twelfth introns of a putative protein-coding gene (BC000061).