Table 1.

Participant demographics stratified by age and absence or presence of AVC

	AVC = 0 (n=5,899)		p-value	AVC >0 (n=911)		p-value
	Age <65 (n=3,645)	Age ≥65 (n=2,257)		Age <65 (n=189)	Age ≥65 (n=722)
Age, years	54.3 (5.7)	71.4 (4.9)	<0.001	58.4 (4.3)	73.7 (5.3)
Women	54.3%	55.8%	0.261	32.8%	41.8%	0.024
Race
White	37.3%	37.6%	0.783	42.3%	46.1%	0.783
Black	27.7&	28.9%	0.287	24.4%	25.7%	0.287
Chinese	23.1%	20.2%	0.008	28.0%	20.3%	0.008
Hispanic	12.0%	13.3%	0.144	5.3%	7.9%	0.144
Systolic blood pressure, mm Hg	120.4 (18.7)	133.1 (22.3)	<0.001	130.1 (20.7)	136.3 (22.3)	<0.001
Diastolic blood pressure, mm Hg	72.4 (10.2)	71.0 (10.4)	<0.001	75.4 (10.4)	71.4 (9.8)	<0.001
Hypertension	46.7%	73%	<0.001	68.8%	80.9%	<0.001
Antihypertensive medication	23.4%	47.4%	<0.001	45.5%	58%	<0.001
LDL-C, mg/dL	118.0 (31.6)	115.3 (29.9)	0.001	129.2 (39.2)	115.9 (32.5)	<0.001
HDL-C, mg/dL	50.3 (14.6)	52.8 (15.2)	<0.001	47.0 (13.2)	49.5 (14.4)	0.036
Triglycerides, mg/dL*	112 (77, 164)	107 (76,155)	0.007	133 (92,186)	118 (82, 166)	0.017
Lipoprotein(a), mg/dL*	16.5 (7, 39)	17.5 (8,38)	0.296	25.4 (9, 67)	19 (8, 52)	0.027
Hyperlipidemia	43.5%	47.8%	<0.001	63.0%	53.6%	0.001
Lipid-lowering medication	11.0%	20.7%	0.001	22.0%	27.2%	<0.001
Glucose, mg/dL	95.3 (30.8)	98.6 (25.9)	<0.001	103.5 (40.4)	102.5 (35.7)	0.739
Diabetes	9.8%	14.1%	<0.001	21.2%	19.5%	<0.001
Body mass index, kg/m2	28.7 (5.7)	27.7 (5.2)	<0.001	30.0 (5.4)	28.1 (4.7)	<0.001
Current smoking	17.0%	7.6%	<0.001	20.1%	8.0%	<0.001
10-year ASCVD risk score, %	6.0 (6.1)	21.1 (12.9)	<0.001	12.0 (8.9)	28.0 (15.1)	<0.001
Coronary artery calcium *	0 (0, 9.6)	25 (0, 173)	<0.001	33 (0, 223)	155 (21, 536)	<0.001
Aortic valve calcium*	0	0	n/a	34.1 (13, 1,113)	69.0 (23, 2,453)	<0.001

^*Median and interquartile range