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. 2025 Nov 2;17(21):3462. doi: 10.3390/nu17213462
TNF-α tumor necrosis factor-alpha
IL interleukin
IGF-1 insulin-like growth factor 1
PI3K phosphatidylinositol 3-kinase
Akt protein kinase B
mTOR mammalian target of rapamycin
ROS reactive oxygen species
NF-κB nuclear factor kappa B
FoxO3a forkhead box O3a (FoxO3a)
RCE Rosa canina extract
p-PI3K phosphorylated-PI3K
p-Akt phosphorylated-Akt
p-mTOR phosphorylated-mTOR
p70S6K 70-kDa ribosomal S6 kinase
p-p70S6K phosphorylated-p70S6K
4EBP1 4E-binding protein 1
p-4EBP1 phosphorylated-4EBP1
DMEM Dulbecco’s modified Eagle’s medium
FBS fetal bovine serum
CON mice received no surgery and were supplemented with saline
IMM mice received immobilization surgery and were supplemented with saline
RCL mice received immobilization surgery and were orally administered RCE at 200 mg/kg/day
RCH mice received immobilization surgery and were orally administered RCE at 400 mg/kg/day
GA gastrocnemius
SOL soleus
TA tibialis anterior
EDL extensor digitorum longus
H&E hematoxylin & eosin
ELISA Enzyme-linked immunosorbent assay
RT-PCR Reverse transcription-polymerase chain reaction
SDS-PAGE sulfate-polyacrylamide gel electrophoresis
TBS-T Tris-buffered saline containing 0.1% Tween 20
ECL enhanced chemiluminescence
SEM standard error of the mean
ANOVA one-way analysis of variance
SOD superoxide dismutase
GPX glutathione peroxidase
MTT thiazolyl blue tetrazolium bromide
MyoD myogenic differentiation 1
MHC myosin heavy chain
MuRF1 muscle ring finger 1
Atrogin-1 muscle atrophy F-box
CSA cross-sectional area