Abbreviation	Full Term
AI	Artificial Intelligence
AMP-224	PD-L2 Fc Fusion Protein
ATM	Ataxia Telangiectasia Mutated (gene)
AURKB	Aurora B Kinase
BED	Biologically Effective Dose
BED10	Biologically Effective Dose using an α/β ratio of 10
BRCA1/2	Breast Cancer Genes 1 and 2
CD	Cluster of Differentiation
CD274	Programmed Death-Ligand 1 (PD-L1)
CEA	Carcinoembryonic Antigen
CRC	Colorectal Cancer
ctDNA	Circulating Tumour DNA
CTV	Clinical Target Volume
dMMR	Deficient Mismatch Repair
DAMP	Damage-Associated Molecular Pattern
EMT	Epithelial–Mesenchymal Transition
ERE	Electron Return Effect
ESMO	European Society for Medical Oncology
EU	European Union
FFCLP	Freedom From Local–Regional Progression
GITR	Glucocorticoid-Induced TNF Receptor
GNL	Gradient Non-Linearity
GSK-3β	Glycogen Synthase Kinase-3 Beta
GTV	Gross Tumour Volume
Gy	Gray (unit of radiation dose)
HR	Hazard Ratio
HIF-1α	Hypoxia-Inducible Factor 1 Alpha
HMGB1	High-Mobility Group Box 1
HR (repair)	Homologous Recombination (DNA repair pathway)
ICD	Immunogenic Cell Death
ICB	Immune Checkpoint Blockade
IL-2	Interleukin-2
IL6R	Interleukin-6 Receptor
IV	Intravenous
KRAS	Kirsten Rat Sarcoma Viral Oncogene Homolog
LC	Local Control
LET	Linear Energy Transfer
M5A-IL2	Immunocytokine targeting CEA linked to IL-2
MDT	Multidisciplinary Team
ML	Machine Learning
MLC	Multi-Leaf Collimator
MMR	Mismatch Repair
MRIgRT	Magnetic Resonance Image-guided Radiotherapy
MRgSBRT	Magnetic Resonance-guided Stereotactic Body Radiotherapy
MR-Linac	Magnetic Resonance Linear Accelerator
MSI-H	Microsatellite Instability-High
NHEJ	Non-Homologous End Joining (DNA repair pathway)
OAR	Organ at Risk
OER	Oxygen Enhancement Ratio
ORCHESTRA	Optimal Treatment for Patients with Oligometastatic Colorectal Cancer
OS	Overall Survival
PFS	Progression-Free Survival
PI3K/AKT	Phosphoinositide 3-Kinase/Protein Kinase B Pathway
PKC	Protein Kinase C
PTV	Planning Target Volume
RILD	Radiation-Induced Liver Disease
RNA-seq	RNA Sequencing
ROS	Reactive Oxygen Species
RSI	Radiosensitivity Index
SABR	Stereotactic Ablative Radiotherapy
SAE	Serious Adverse Event
SBRT	Stereotactic Body Radiotherapy
SRS	Stereotactic Radiosurgery
STING	Stimulator of Interferon Genes
TAAs	Tumour-Associated Antigens
TGFβ	Transforming Growth Factor Beta
TNT	Total Neoadjuvant Therapy
TP53	Tumour Protein 53
UK	United Kingdom
US	United States
VEGF	Vascular Endothelial Growth Factor