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. 2025 Nov 4;30(21):4290. doi: 10.3390/molecules30214290
177Lu Lutetium-177
TRT Targeted radiation therapy
MNPs Magnetic nanoparticles
NPs Nanoparticles
MRI Magnetic resonance imaging
SPECT Single Photon Emission Computed Tomography
PET Positron Emission Tomography
ICRP International Commission on Radiological Protection
Lutathera® [177Lu]Lu-DOTATATE
Pluvicto® [177Lu]Lu-Vivipotide tetraxetan
PRRT Peptide receptor radionuclide therapy
CuAAC Copper(I)-catalyzed azide-alkyne cycloaddition
SPAAC Strain-promoted azide-alkyne cycloaddition
IEDDA Inverse-electron-demand Diels–Alder
CBT 2-cyanobenzothiazole
NTA Nitrilotriacetic acid
EDTA Ethylenediaminetetraacetic acid
DTPA Diethylenetriaminepentaacetic acid
DOTA 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid
DO3A 1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid
NOTA 1,4,7-Triazacyclononane-1,4,7-triacetic acid
NOTAGA (NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) + GA (glutaric acid))
NETA {4-[2-(bis-carboxymethylamino)-ethyl]-7-carboxymethyl-[1,4,7]-triazonan-1-yl}-acetic acid
DOTRP 1,4,7,10-tetraazacyclodecane-1,4,7,10-tetra(R)ester phosphinic acid
NORP 1,4,7-teriazacyclononane-1,4,7-tri(R)esterphosphinic acid
177Hf Hafnium-177
176Yb Ytterbium-176
176Lu Lutetium-176
169Yb Ytterbium-169
175Yb Ytterbium-175
177Yb Ytterbium-177
SA Specific activity
GEP-NETs Gastroenteropancreatic neuroendocrine tumors
PPGLs Pheochromocytomas and paragangliomas
LAR Long-acting repeatable
SSTR2 Somatostatin Receptor 2
mCRPC Metastatic castration-resistant prostate cancer
PI(s) Principal investigator(s)
PSMA Prostate-specific membrane antigen
PET/CT Positron emission tomography/Computed tomography
NETs Neuroendocrine tumors
EPR Enhanced permeability and retention
MIONPs Magnetic iron oxide NPs
IONPs Iron oxide NPs
SPIONPs Superparamagnetic iron oxide NPs
SPIO Superparamagnetic iron oxide
Fe3O4 Magnetite
γ-Fe2O3 Maghemite
PEG Polyethylene glycol
co-CNCs Condensed colloidal nanocrystal clusters
MA Alginate-coated nanocrystallites
MAPEG PEGylated MA
Dh Hydrodynamic diameter
DLS Dynamic light scattering
ITLC-SG Instant Thin Layer Chromatography-Silica Gel
NBT Nanobrachytherapy
DMSA Meso-1,2-dimercaptosuccinic acid
TEM Transmission electron microscopy
PDI Polydispersity index
XRD X-ray diffraction
FT-IR Fourier-transform infrared
CA Citric acid
PAA Poly(acrylic acid)
SAED Selected-area electron diffraction
MS Saturation magnetization
EDC N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide
NHS N-hydroxysuccinimide
AA Alginic acid
DOX Doxorubicin
BVCZ Bevacizumab
HPLC High-performance liquid chromatography
TGA Thermogravimetric analysis
RP-HPLC Reverse-phase high-performance liquid chromatography
PBS Phosphate-buffered saline
HIR Heat-induced radiolabeling
FH Feraheme
CMD Carboxymethyldextran
ICP-MS Inductively coupled plasma mass spectrometry
SEC Size exclusion chromatography
LAGMERAL Ligand Anchoring Group-Mediated Radiolabeling
DP-PEG Diphosphonate-polyethylene glycol
FBS Fetal bovine serum
ccDTPA Cyclohexane-1,4-diyldinitrilo)tetraacetic acid dianhydride
MACS Magnetic-assorting cell separation
PCS Photon correlation spectroscopy
PLL Poly-L-lysine
SAR Specific absorption rate
Pro Proline
Trp Tryptophan
UV-Vis Ultraviolet-Visible
DCS Differential centrifugal sedimentation
HA Hyaluronic acid
DBCO Dibenzocyclooctyne
177Lu-TCL-SPIONPs 177Lu-labeled thermally cross-linked SPIONPs
RES Reticuloendothelial system
VEGF Vascular Endothelial Growth Factor
NMIBC Nonmuscle-invasivebladder cancer
MIBC Muscle-invasive bladder cancer
177Lu-MNFs 177Lu-labeled magnetic nano-formulations
GMP Good Manufacturing Practice
RCY Radiochemical yield
RCP Radiochemical purity