Table 3.
Relevant examples of circular RNAs implication in neuropathic pain
| Circular RNA | Downstream target(s) | Model(s) | Disease background | Biological function in the occurrence and development of neuralgia |
|---|---|---|---|---|
| CircZNF609 | miR-22-3p | CCI rats | Neuropathic pain | ↑ |
| CircAnks1a | miR-324-3p | SNL rats | Neuropathic pain | ↑ |
| Circ_0005075 | miR-151a-3p | CCI rats | Neuropathic pain | ↑ |
| ciRs-7 | miR-135a-3p | CCI rats | Neuropathic pain | ↑ |
| zRANB1 | miR-24-3p | CCI rats | Neuropathic pain | ↓ |
| CircularRNA-Filip1l | Ubr5 | CFA mice | Neuroinflammation | ↑ |
| circHIPK3 | miR-124 | DNP rats | DNP | ↑ |
| SMEK1 | miR-216-5p | CCI rats | Neuropathic pain and neuroinflammation | ↑ |
| circRNA.2837 | miR-34 family | SNI rats | Neuropathic pain | ↑ |
| ciRNA-Kat6b | miRNA-26a | CCI mice | Neuropathic pain | ↓ |
| Circular RNA-GRIN2B | NF-κB/SLICK pathway | CCI rats | Neuropathic pain | ↓ |
| circ_lrrc49 | Ist1 | CCI-ION mice | Neuropathic pain | ↑ |
↑Signifies the facilitation of the onset and progression of neuralgia.
↓Signifies the alleviation of neuralgia symptoms.