Figure 2. Views of Structural Representatives from Six Families in the Kinase-Like Superfamily Other Than the TPKs.

Structures are shown in an open-face view, and using the same conventions as used for PKA in Figure 1. ATP and metal ions are shown in mirror image where available in the structure. Similar to Figure 1, secondary structural elements are colored according to their conservation status in the overall superfamily as follows: yellow, elements are part of the “universal core” seen in all kinases in the superfamily; orange, elements are present in more than two, but not all, of the kinases in the superfamily; red, elements shared between only two families; purple, elements seen only in this family, but inserted within in the portion of the chain forming the universal core; blue, elements seen only in this family, and connected to the N- or C-terminal ends of the universal core. Secondary structural elements are labeled according to the standard conventions for the individual structure. As in Figure 1, the glycine-rich loop is rendered in green and the loop forming the linker region is rendered in red. For clarity, the conserved residues shown in Figure 1 are not rendered in these structures, though in most cases they are similar. Structures shown are as follows: (A) aminoglycoside phosphotransferase (APH(3′)-IIIa [24]); (B) CK (CKA-2 [23]); (C) ChaK [20]; (D) PI3K [21]; (E) AFK [22]; and (F) PIPKIIβ [19]. Molecular renderings in this figure were created with MOLSCRIPT [90].