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. 2005 Oct 21;1(5):e49. doi: 10.1371/journal.pcbi.0010049

Figure 5. Shared Hydrogen-Bonding Networks between Distantly Related Structures in the Kinase-Like Superfamily.

Figure 5

Colors and nomenclature for secondary structural elements are identical to those provided in Figure 2. Structures shown are the C-terminal subdomains of four structures: (A) PKA [70]; (B) CKA-2 [23]; (C) PI3K [21]; and (D) AFK [22]. For clarity, some portions of structures are omitted. Residues involved in the shared hydrogen-bond networks are shown in a ball-and-stick rendering. For clarity, side-chains are omitted for residues that only participate in the network via backbone interactions. Residues involved directly in catalysis or metal binding are shown with light-green stick regions in the ball-and-stick rendering. Metal atoms, when present, are shown as gray spheres. ATP (or ATP analog), when present, is shown in a line rendering. Hydrogen bonds are shown in cyan. The orientation of the structures is similar but not identical (structures were rotated somewhat to make H-bond contacts more visible). Molecular renderings in this figure were created with MOLSCRIPT [90].