Fig. 8. LDH substrates regulate KATP channel-mediated membrane current. (A) Membrane currents and corresponding current–voltage relationships in cells filled with pipette solution containing NADH (20 mM) or pyruvate (20 mM) or both. Arrow points to the zero current level. (A1) Current densities at 80 mV for conditions in (A). Vertical bars represent mean ± SEM (n = 6–9). *P <0.01. (B) Membrane currents and corresponding current–voltage relationships in cells filled with pipette solution containing NAD (20 mM) or lactate (20 mM) or both. Arrow points to the zero current level. In all experiments depicted cells were dialysed for ∼5 min. (B1) Current densities at 80 mV under conditions in (B). Vertical bars represent mean ± SEM (n = 6–9). *P <0.05.