Table 1.
Cohort characteristics stratified by platelet slope pattern after CRRT initiation
| Overall (n = 2226) |
Descending (n = 655) |
Stable (n = 1297) |
Ascending (n = 274) |
p | ||
|---|---|---|---|---|---|---|
| Baseline Characteristics | ||||||
| Age (years) | 59 [48, 69] | 60 [49, 69] | 59 [48, 69] | 56.50 [43, 67] | 0.003 | |
| Female sex | 869 (39.0) | 269 (41.1) | 502 (38.7) | 98 (35.8) | 0.297 | |
| Race Black | 752 (33.8) | 224 (34.2) | 410 (31.6) | 118 (43.1) | 0.004 | |
| White | 1334 (59.9) | 397 (60.6) | 797 (61.4) | 140 (51.1) | ||
| Other | 140 (6.3) | 34 (5.2) | 90 (6.9) | 16 (5.8) | ||
| Body weight at ICU admission (kg) |
91.7 [77.0, 111.1] |
91.2 [76.7, 111.9] |
90.9 [75.9, 109.1] |
97.8 [82.1, 116.8] |
0.001 | |
| Charlson Comorbidity Index | 3 [0, 4] | 3 [0, 4] | 3 [0, 4] | 2 [0, 4] | 0.001 | |
| Diabetes Mellitus | 865 (38.9) | 264 (40.3) | 490 (37.8) | 111 (40.5) | 0.466 | |
| Hypertension | 1175 (52.8) | 367 (56.0) | 652 (50.3) | 156 (56.9) | 0.019 | |
| Cardiovascular disease | 1413 (63.5) | 417 (63.7) | 819 (63.1) | 177 (64.6) | 0.896 | |
| Coronary artery disease | 1067 (47.9) | 307 (46.9) | 617 (47.6) | 143 (52.2) | 0.308 | |
| Liver disease | 454 (20.4) | 125 (19.1) | 310 (23.9) | 19 (6.9) | < 0.001 | |
| Chronic kidney disease | 873 (39.2) | 269 (41.1) | 517 (39.9) | 87 (31.8) | 0.023 | |
| Baseline SCr (mg/dL) |
1.20 [0.90, 2.00] |
1.20 [0.90, 1.95] |
1.30 [0.90, 2.00] |
1.20 [0.80, 1.98] |
0.154 | |
| SOFA score at ICU admission | 9 [6, 12] | 8 [6, 11] | 9 [6, 12] | 8 [5, 11] | 0.002 | |
| SOFA score at CRRT initiation | 12 [9, 14] | 11 [8, 13] | 12 [9, 15] | 11 [9, 14] | < 0.001 | |
|
Number of vasopressors at CRRT initiation |
1 [0, 2] | 1 [1, 3] | 1 [0, 3] | 1 [0, 2] | < 0.001 | |
| Use of inotropes at CRRT initiation | 527 (23.7) | 136 (20.8) | 335 (25.8) | 56 (20.4) | 0.018 | |
| Sepsis * | 2058 (92.5) | 614 (93.7) | 1190 (91.8) | 254 (92.7) | 0.287 | |
| MV * | 1705 (76.6) | 491 (75.0) | 985 (75.9) | 229 (83.6) | 0.013 | |
| ECMO * | 149 (6.7) | 36 (5.5) | 103 (7.9) | 10 (3.6) | 0.012 | |
| VAD * | 84 (3.8) | 15 (2.3) | 60 (4.6) | 9 (3.3) | 0.034 | |
| Heparin exposure * | 1596 (71.7) | 468 (71.5) | 908 (70.0) | 220 (80.3) | 0.003 | |
| Clinical Outcomes | ||||||
| In-hospital mortality | 1287 (57.8) | 412 (62.9) | 781 (60.2) | 94 (34.3) | < 0.001 | |
| Hospital length of stay (days) | 20 [11, 36] | 20 [10, 34.50] | 19 [10, 33] | 27 [17, 43.75] | < 0.001 | |
| ICU length of stay (days) | 13 [7, 24] | 12 [7, 22] | 13 [7, 24] | 18 [11, 29] | < 0.001 | |
| 28-day ICU-free days | 0 [0, 12] | 0 [0, 10] | 0 [0, 11] | 2 [0, 15] | < 0.001 | |
| Total duration of CRRT (days) | 7 [3, 13] | 6 [4, 11] | 7 [3, 13] | 9 [6, 15] | < 0.001 | |
| 28-day CRRT-free days | 0 [0, 19] | 0 [0, 19] | 0 [0, 18] | 13.5 [0, 20] | < 0.001 | |
Abbreviation: AKI, acute kidney injury; CRRT, continuous renal replacement therapy; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; MV, mechanical ventilation; SCr, serum creatinine; SOFA, Sequential Organ Failure Assessment; VAD, ventricular assist device
Categorical variables are presented as n (%), and numerical variables are presented as median [IQR]
* Determined as exposure between ICU admission and CRRT initiation