| α3 |
Disorganized basement membrane; occasional epidermal/dermal blistering, primarily on legs and footpads |
DiPersio et al. (1997) |
| β6 |
Juvenile hair loss due to macrophage infiltration into skin; wound healing normal |
Huang et al. (1996) |
| α9 |
No defects observed |
Huang et al. (2000b) |
| β5 |
Wound healing normal |
Huang et al. (2000a) |
| β1 |
Floxed β1 × K5Cre |
Brakebusch et al. (2000) |
| |
Abnormal hair follicles; hair loss with removal of follicles by infiltrating macrophages; epidermal/dermal blisters; reduced proliferation and abnormal differentiation of IFE; disruption of basement membrane; reduced α6β4 expression; reduced hemidesmosomes; dermal fibrosis; impaired wound healing |
Grose et al. (2002) |
| |
Floxed β1 × K14Cre |
Raghavan et al. (2000) |
| |
Epidermal/dermal blistering; basement membrane disruption; reduced hemidesmosomes; thin epidermis; reduced number of hair follicles; reduced α6β4 expression |
|
| α6 |
Severe epidermal blistering |
Georges-Labouesse et al. (1996) |
| β4 |
Severe epidermal blistering; absence of hemidesmosomes |
Van der Neut et al. (1996) |
| |
|
Dowling et al. (1996) |
| α3 + α6 |
Epidermal blistering; proliferation, stratification and hair follicle morphogenesis normal in adherent epidermis |
DiPersio et al. (2000a) |
| α2 |
No epidermal defects observed, wound healing not impaired |
Chen et al. (2002) Holtkötter et al. (2002)
|
