Table 2.

Growth factors determined by real-time PCR. Among growth factors and receptors that were described to be regulated, TSP-1, VEGF-R1 (Flt), PDGF-B, Serum Response Factor (SRF), TGF-β 1, Angiopoietin Receptor 2 (TIE2) and FGF-2 were separately determined by relative mRNA quantification after laser-microdissection from 1 and 7 day hypoxic/normoxic intrapulmonary arteries. Mean ± SEM is given from n = 4 independent experiments.

Genes	1 Day Hypoxia	7 Days Hypoxia
Thrombospondin 1 (TSP-1)	4.61 ± 0.79	1.95 ± 0.44
VEGF-R1/FLT1	2.38 ± 0.43	0.61 ± 0.13
PDGF-β	1.41 ± 0.28	2.96 ± 0.82
Serum Response Factor (SRF)	1.09 ± 0.08	1.70 ± 0.29
Transforming Growth Factor β 1 (TGF-β 1)	0.94 ± 0.14	2.10 ± 0.46
Angiopoietin Receptor 2 (TIE2)	0.91 ± 0.09	1.94 ± 0.21
Fibroblast Growth Factor 2 (FGF-2)	0.75 ± 0.14	0.80 ± 0.15